L-Histidine mono-Hydrochloride 1-hydrate 100 g
PRODUCT CODE: 142198
L-Histidine mono-Hydrochloride 1-hydrate (BP, Ph. Eur.) pure, pharma grade
C6H10ClN3O2.H2O
C6H9N3O2HCl.H2O
M.= 209,63 CAS [5934-29-2] EINECS 211-438-9
TARIC 2933 29 90 90
SYNONYMS: (S)-2-Amino-3-(4-Imidazolyl) Propionic Acid mono-Hydrochloride•
PHYSICAL DATA: crystalline powder, White, Soluble in water 400 g/l at 20 °C M.P.: 254 °C • pH(10% sol.)3,5 - 4,5 •
BIBLIOGRAPHY: Merck Index 12, 4.758 13, 4.741 Safety 2 , 1878 D • Römp 8 , 1711 • Beilstein 25 , 513 IV , 4346 • BRN 84088 • BP. 2014 • Ph. Eur. 7.0 (2013) 8.0 (2014) • F.C.C 8 9 • Royal Decree I1114 •
OBSERVATIONS: Storage away from direct light.
SPECIFICATIONS:
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Assay (Arg.) (calc. a.a.s)
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98,5-101,0%
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Identity :
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Identity according to Pharmacopoeias
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Passes test
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pH of 5% solution
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3,0-5,0
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T.L.C.
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Passes test
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Specific rotation [a] 20/D c=11, (in HCl 6 mol/l)
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+9,2 a +10,6°
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MAXIMUM LIMIT OF IMPURITIES
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Appearance of solution
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Passes test
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Insoluble matter in H2O
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Passes test
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Loss on drying at 150°C
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7,0-10,0 %
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Residue on ignition (as SO4)
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0,1 %
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Ammonium (NH4)
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0,02%
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Sulphate (SO4)
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0,03%
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Heavy metals (as Pb)
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0,001%
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Residual metals ICP: (according to EMEA/CHMP/SWP/4446/2000)
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Class 1A (Pt, Pd)
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10 ppm
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Class 1B (Ir, Rh, Ru, Os)
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10 ppm
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Class 1C (Mo, Ni, Cr, V)
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25 ppm
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Class 2 (Cu, Mn)
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250 ppm
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Class 3 (Zn)
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1.300 ppm
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As
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0,00015 %
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Fe
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0,001 %
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